The Science Behind Spravato & Ketamine Treatment
Spravato and ketamine are different from traditional antidepressants. Rather than targeting serotonin or norepinephrine, they work through NMDA receptor modulation — helping the brain form new connections and "reset" certain signaling pathways. For many patients, that can translate into meaningful symptom relief — often faster than conventional options.
At Haven Health, both Spravato and ketamine treatments are provided onsite in a monitored medical setting, with time in the center treated as part of the healing process.
Spravato: FDA-Approved Treatment for Treatment-Resistant Depression
Spravato (esketamine) is the first FDA-approved nasal spray specifically indicated for treatment-resistant depression and major depressive disorder with suicidal ideation. It's covered by most major insurance carriers.
FDA-approved: Specifically indicated for treatment-resistant depression and MDD with suicidal ideation.
Insurance covered: Accepted by nearly all major carriers, making it accessible for more patients.
Structured Spravato care: Each 2-hour session is administered onsite under supervision with follow-up calls after treatment.
Ketamine Infusions for Treatment-Resistant Depression
For people who have tried multiple antidepressants without adequate relief, IV ketamine infusions may offer a new path forward.
Fast-acting relief: Some patients report improvement within hours to days rather than weeks.
Hope after multiple failed antidepressants: Designed for treatment-resistant depression — commonly defined as inadequate response to at least two antidepressant trials.
Continuous monitoring: A critical-care RN stays by your side throughout every ketamine infusion.
What Treatment Looks Like at Haven Health
Haven Health provides the treatment setting while patients continue broader care with their primary doctor.
Spravato
Initial Phase
Twice weekly × 4 weeks, then weekly × 4 weeks, then every 2 weeks × 4 weeks
Maintenance
Treatments as needed
Ketamine Infusions
Initial Phase
Six one-hour infusions over three weeks
Maintenance
Single two-hour infusion as needed
Safety & Monitoring
IV ketamine infusions: Continuous monitoring by a critical-care RN
Spravato: Monitored per REMS protocol during each 2-hour session
Post-treatment follow-up: Follow-up calls after every treatment session
Ready to learn more about Spravato or ketamine treatment?
Talk to our team to see if Spravato or ketamine therapy may be right for you, or have your doctor refer you.